LYMPHOID NEOPLASIA MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
نویسندگان
چکیده
1Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; 2Unit of Blood Diseases and Cell Therapies, University of Brescia Medical School, Brescia, Italy; 3Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy; 4Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston; 5Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy; and 6Department of Hematology, Mayo Clinic, Rochester, MN
منابع مشابه
MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.
Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple myeloma (MM) pathogenesis and disease progression. Nevertheless, little is known about the characteristics of MM at the epigenetic level and specifically how microRNAs regulate MM progression in the context of the bone marrow milieu. Therefore, we performed microRNA expression profiling of bone marrow deri...
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BACKGROUND miR-15a and miR-16-1(miR-15a/16-1) have been implicated as tumor suppressors in chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemic cells. However the mechanism of inhibiting the proliferation of leukemic cells is poorly understood. METHODS K562 and HL-60 cells were transfected with pRS-15/16 or pRS-E, cell growth were measured by CCK-8 assay and direct cell ...
متن کاملmiR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF.
Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a and miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2, have been implicated in cell cycle, apoptosis and proliferation. In this study, we investigated the possible role of miR-15a/16 in the angiogenesis of multiple myeloma (MM). Using a stem-loop ...
متن کاملMicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.
Multiple myeloma is characterized by frequent chromosomal alterations. Deletion of chr 13, especially band 13q14, is commonly observed in early stages of MM, suggesting the presence of tumor suppressor genes within this region. Here, we functionally validate the role of the microRNAs-15a/16-1 cluster, centered at the deleted region, as TSGs and delineate their downstream target genes in MM. Usi...
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BACKGROUND MicroRNAs (miRNAs) are short, noncoding RNAs that regulate the expression of multiple target genes. Deregulation of miRNAs is common in human tumorigenesis. The miRNAs, MIR-15a/16-1, at chromosome band 13q14 are down-regulated in the majority of patients with chronic lymphocytic leukaemia (CLL). METHODOLOGY/PRINCIPAL FINDINGS We have measured the expression of MIR-15a/16-1, and 92 ...
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